Global collaborative effort to monitor and drug the brain as nimbly as possible was achieved last month. By probing the victim with a brain implant consisting of a “plug-n-play” drug-cartridge, as thin as a Human hair and consisting of microfluidic channels and tiny LEDs smaller than a grain of salt, the scientists have the ability to harness its unlimited supply of drug doses and to deliver light to the targeted neurons. This, being connected and maneuvered through a smart phone allows scientists to disrupt the cerebral neurons in hope to treat addictions, pain, and emotional disorders within the patient. As you can imagine, while it certainly has great potential to help Humanity, there lies equally the dark desire to destroy health, beauty, and free will in an attempt to suppress the ever-throbbing Heart that powers all life throughout the Universe.
However, only last week did they make another advance in neurotechnology whereby the artificial maneuvering of neurons via mesh electronics have been created to assist the treatment of diseases such as Parkinson’s and Alzheimer’s. As Shaun Patel on the project says, “The next frontier is really the merging of human cognition with machines.” Unlike the current electrodes that the body’s natural neural immune cells, or glia cells, would perceive as alien and would overtime destroy the intruder, a new device has been built to ensure that these glia cells would not react to these foreign devices, thus busting through its firewalls and permitting the mechanical virus to remain. Using mesh electronics to zap areas of the brain and eliminate these unwanted side effects of glia cells, this has the special ability to stimulate neural migration where they may redirect newborn neurons to damaged parts of the brain.
It should be noted that “during his postdoctoral studies, Patel saw how just a short pulse of electricity – no more than 500 milliseconds of stimulation – could control a person’s ability to make a safe or impulsive decision. After a little zap, subjects who almost always chose the risky bet, instead went with the safe option. ‘You would have no idea that it’s happened,’ Patel said. ‘You’re unaware of it. It’s beyond your conscious awareness.’”
Even more unnerving is that “a few major technology companies are also eager to champion brain-machine interfaces. Some, like Elon Musk’s Neuralink, which plans to give paralyzed patients the power to work computers with their minds, are focused on assistive applications. Others have broader plans: Facebook wants people to text by imaging the words, and Brian Johnson’s Kernel hopes to enhance cognitive abilities.”
“‘One does need to be a little careful about the ethics involved if you’re trying to make a superhuman,’” the project’s Professor Charles M. Lieber said.
But the question is…will these big tech companies heed his warning when money is unable to see the difference between right and wrong, Truth and trickery, the infinitely vast Heart versus the false promise of a great Mind?
Featured below on this same page, the first article where I gathered this information is from:
And the second article, featured on page 2, is from:
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“A team of scientists in Korea and the United States have invented a device that can control neural circuits using a tiny brain implant controlled by a smartphone.
Researchers, publishing in Nature Biomedical Engineering, believe the device can speed up efforts to uncover brain diseases such as Parkinson’s, Alzheimer’s, addiction, depression, and pain.
The device, using Lego-like replaceable drug cartridges and powerful bluetooth low-energy, can target specific neurons of interest using drug and light for prolonged periods.
‘The wireless neural device enables chronic chemical and optical neuromodulation that has never been achieved before,’ said lead author Raza Qazi, a researcher with the Korea Advanced Institute of Science and Technology (KAIST) and University of Colorado Boulder.
Qazi said this technology significantly overshadows conventional methods used by neuroscientists, which usually involve rigid metal tubes and optical fibers to deliver drugs and light. Apart from limiting the subject’s movement due to the physical connections with bulky equipment, their relatively rigid structure causes lesion in soft brain tissue over time, therefore making them not suitable for long-term implantation. Though some efforts have been put to partly mitigate adverse tissue response by incorporating soft probes and wireless platforms, the previous solutions were limited by their inability to deliver drugs for long periods of time as well as their bulky and complex control setups.
To achieve chronic wireless drug delivery, scientists had to solve the critical challenge of exhaustion and evaporation of drugs. Researchers from the Korea Advanced Institute of Science and Technology and the University of Washington in Seattle collaborated to invent a neural device with a replaceable drug cartridge, which could allow neuroscientists to study the same brain circuits for several months without worrying about running out of drugs.
These ‘plug-n-play’ drug cartridges were assembled into a brain implant for mice with a soft and ultrathin probe (thickness of a human hair), which consisted of microfluidic channels and tiny LEDs (smaller than a grain of salt), for unlimited drug doses and light delivery.
Controlled with an elegant and simple user interface on a smartphone, neuroscientists can easily trigger any specific combination or precise sequencing of light and drug deliveries in any implanted target animal without need to be physically inside the laboratory. Using these wireless neural devices, researchers could also easily setup fully automated animal studies where behaviour of one animal could positively or negatively affect behaviour in other animals by conditional triggering of light and/or drug delivery.
‘This revolutionary device is the fruit of advanced electronics design and powerful micro and nanoscale engineering,’ said Jae-Woong Jeong, a professor of electrical engineering at KAIST. ‘We are interested in further developing this technology to make a brain implant for clinical applications.’
Michael Bruchas, a professor of anesthesiology and pain medicine and pharmacology at the University of Washington School of Medicine, said this technology will help researchers in many ways.
‘It allows us to better dissect the neural circuit basis of behaviour, and how specific neuromodulators in the brain tune behaviour in various ways,’ he said. ‘We are also eager to use the device for complex pharmacological studies, which could help us develop new therapeutics for pain, addiction, and emotional disorders.’
The researchers at the Jeong group at KAIST develop soft electronics for wearable and implantable devices, and the neuroscientists at the Bruchas lab at the University of Washington study brain circuits that control stress, depression, addiction, pain and other neuropsychiatric disorders. This global collaborative effort among engineers and neuroscientists over a period of three consecutive years and tens of design iterations led to the successful validation of this powerful brain implant in freely moving mice, which researchers believe can truly speed up the uncovering of brain and its diseases.
This work was supported by grants from the National Research Foundation of Korea, U.S. National Institute of Health, National Institute on Drug Abuse, and Mallinckrodt Professorship.”
Materials provided by University of Washington Health Sciences/UW Medicine. Note: Content may be edited for style and length.
- Raza Qazi, Adrian M. Gomez, Daniel C. Castro, Zhanan Zou, Joo Yong Sim, Yanyu Xiong, Jonas Abdo, Choong Yeon Kim, Avery Anderson, Frederik Lohner, Sang-Hyuk Byun, Byung Chul Lee, Kyung-In Jang, Jianliang Xiao, Michael R. Bruchas, Jae-Woong Jeong. Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation. Nature Biomedical Engineering, 2019; DOI: 10.1038/s41551-019-0432-1