This talk on several spiritually-inclined websites about 10 out of 12 DNA strands lying deactivated within the Human DNA structure might indeed make sense, however it is thought that these 10 reside in what is known as “junk DNA”. I did further search into this and found that this “junk DNA”, or pericentromeric satellite DNA, are repetitions throughout the genome that fiercely hold together the chromosomes.
What strikes me as a bit off is that if this “junk DNA” is but repetitions of the same set of genetic code, then it must not represent the “10 dormant strands of DNA” as it would infer that those repetitions are a series of different sets instead, leaving the original set with the “2 active strands”.
So while some of these spiritual explanations of DNA may seem logical, this part at least seems to violate scientific evidence.
“Researchers at the University of Michigan Life Sciences Institute and the Howard Hughes Medical Institute have determined how satellite DNA, considered to be ‘junk DNA,’ plays a crucial role in holding the genome together.
Their findings, published recently in the journal eLife, indicate that this genetic ‘junk’ performs the vital function of ensuring that chromosomes bundle correctly inside the cell’s nucleus, which is necessary for cell survival. And this function appears to be conserved across many species.
This pericentromeric satellite DNA consists of a very simple, highly repetitive sequence of genetic code. Although it accounts for a substantial portion of our genome, satellite DNA does not contain instructions for making any specific proteins. What’s more, its repetitive nature is thought to make the genome less stable and more susceptible to damage or disease. Until fairly recently, scientists believed this so-called ‘junk’ or ‘selfish’ DNA did not serve any real purpose.
‘But we were not quite convinced by the idea that this is just genomic junk,’ said Yukiko Yamashita, research professor at the LSI and lead author on the study. ‘If we don’t actively need it, and if not having it would give us an advantage, then evolution probably would have gotten rid of it. But that hasn’t happened.’
Yamashita and her colleagues decided to see what would happen if cells could not use this pericentromeric satellite DNA. Because it exists in long, repetitive sequences, the researchers could not simply mutate or cut the entire satellite DNA out of the genome. Instead, they approached the question through D1, a protein known to bind to satellite DNA.
The researchers removed D1 from the cells of a commonly used model organism, Drosophila melanogaster (fruit flies). And the team quickly noticed that germ cells — the cells that ultimately develop into sperm or eggs — were dying.
Further analysis revealed that the dying cells were forming micro-nuclei, or tiny buds, outside the nucleus that included pieces of the genome. Without the entire genome encapsulated in the nucleus, the cells could not survive.
The researchers believe that the D1 protein binds onto the satellite DNA to pull all of the chromosomes together in the nucleus. If the D1 protein cannot grab the satellite DNA, the cell loses its ability to form a complete nucleus and ultimately dies.
‘It’s like forming a bouquet,’ said Yamashita, who is also a professor of cell and developmental biology at the U-M Medical School and an HHMI investigator. ‘The protein has multiple binding sites, so it can bind onto multiple chromosomes and package them together in one place, preventing individual chromosomes from floating out of the nucleus.’
The team conducted similar experiments using mouse cells and found the same results: When they removed a protein that normally binds to mouse satellite DNA, the cells again formed micro-nuclei and did not survive.
The similar findings from both fruit fly and mouse cells lead Yamashita and her colleagues to believe that satellite DNA is essential for cellular survival, not just in model organisms, but across species that embed DNA into the nucleus — including humans.
The research was supported by the Howard Hughes Medical Institute, the National Institutes of Health and the American Heart Association.”
Materials provided by University of Michigan. Note: Content may be edited for style and length.
- Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita. A conserved function for pericentromeric satellite DNA. eLife, 2018; 7 DOI: 10.7554/eLife.34122
You may also find this article here at: https://www.sciencedaily.com/releases/2018/04/180411131659.htm